This paper examines Wolbachia's efficacy for blocking dengue virus replication in the Aedes aegypti mosquito. The authors examine the saliva of mosquitoes to provide a more accurate assessment of Wolbachia's ability to limit disease transmission. Results suggest that the wMel strain of Wolbachia may have positive impacts on dengue transmission not only by reducing the number of infectious mosquitoes in a population but also delaying the arrival of virus in the saliva.