This study examines the various stages in the DENV infection process to better understand the mechanism of Wolbachia-mediated virus blocking (WMVB). The results suggest that infection with Wolbachia does not inhibit DENV binding or cell entry‚ but reduces virus replication. In contrast to a previous report‚ researchers observed a similar reduction in replication of West Nile virus (WNV). This reduced replication is associated with rapid viral RNA degradation in the cytoplasm.