The paper details the development of a mosquito cell line-based model to dissect the functional and cellular mechanisms of Wolbachia-mediated viral inhibition. We show that cell lines infected with Wolbachia display limited dengue virus replication and protection from virus-induced mortality. The extent of viral inhibition is strongly correlated with Wolbachia density per cell‚ suggesting competition for cellular resources may underlie this phenotype.
Want to learn more about the World Mosquito Program and our sustainable and nature-based Wolbachia method?
Be part of our journey to protect the lives of millions of people.
Subscribe to our newsletter to up to date with global progress in the fight against mosquito-borne disesases.